Portable DNA sequencing and computing technologies have great potential for point-of-care solutions with real-time results. In this talk I will outline how we have used the Oxford Nanopore portable genomics technology to sequence whole plant virus genomes on the farms in Uganda, Tanzania and Kenya. I will also cover the gaps in computing we have identified with our on farm genomic sequencing and discuss potential applications for biosurveillance.

Modern life science R&D engines typically consist of several specialized units or laboratories that each deal with a particular step in the drug discovery process. This in turn requires smart planning and tracking features, i.e., capturing operational data, to be able to keep cycle times to a minimum, especially if other organizations or partners fulfill certain steps in such a process. This talk aims at identifying the essential requirements of a ‘Scientific Operational Data (SODA) management system’ for the life science research space and how it can digitally augment the innovation process by enabling just-in-time operations and supporting data-driven decision-making.

Selecting the right methodology for executing the project will lead to successful delivery and provide business value. With this presentation, you will learn how and which methodology will work for your projects based on the selected project parameters. Selection from Waterfall to Agile to Hybrid methodologies and the deliverables associated with them will help you understand the project needs and deliver benefits while identifying the right resources, budget and timeline.

Early R&D poses many questions and challenges when determining if a therapeutic enters the portfolio. In this presentation we will demonstrate how our new interactive software tool systematically investigates the therapeutic characteristics (e.g., format, half-life, affinity, mechanism of action) given target characteristics (e.g., target expression and turnover) necessary to achieve success criteria given the predetermined target profile to help accelerate and de-risk your project. 

Research projects can only move as fast as a scientist’s ability to find, order, and receive their requested material. Therefore, providing a standardized platform for the identification of requested research material across multiple inventory database software platforms (registries) is essential for Amgen’s highest priority drug discovery projects. In our experience, a single registry cannot adequately identify and characterize the wide variety of multi-modality research materials being generated at Amgen. We will present how the integration of OIL with our Mosaic inventory management platform provides a single point of access for scientists around the world to search and request any research material efficiently and effectively, regardless of which registry contains it.

AutoLab is a laboratory workflow orchestration platform that enables the creation of true digital lab workflows to take scientists one step closer to the Lab of Future dream. AutoLab is capable of seamlessly integrating devices and other applications in an-easy-to use digital workflow, guiding the scientist in their daily work and automating several time-consuming tasks. In this presentation, I will present the challenges that lead to the development of such a platform, how AutoLab is helping Roche pRED overcome them, and how we are using AutoLab to catalyze the digital transformation of pharma research at Roche .

Executives responsible for Clinical Operations face increasing pressures to reduce costs, meet ever aggressive timelines and improve productivity of Trial Execution Teams. The Nurocor automation solution saves, conservatively, $8,000,000 and 8 months on a typical Phase 3 trial. The Nurocor solution provides quality by design planning and execution, maximizing the value of existing systems through built in connectivity, and enables high value staff to focus on critical tasks not the mundane. 

Collaborative Drug Discovery (CDD) provides a whole solution for today’s biological and chemical data needs, differentiated by ease-of-use and superior collaborative capabilities. CDD Vault® software includes Activity & Registration, Visualization, Inventory, and ELN capabilities. Researchers can archive, mine, and securely collaborate within CDD Vault. Collaborative hypothesis generation and evaluation allow multiple perspectives for multi-parameter optimization. 

Data is everywhere, but where is the patient in the equation? Everyone is talking about patient-centricity. But is it just a buzz word? A latest fad or something that can be enable by technology and design to reach through and make engage patients throughout the clinical trial process and beyond. How can a platform technology leverage the patients themselves to breakdown their data silos and in doing so enhance patient engagement, patient onboard, study and drug compliance and study outcome? That is Seqster. 

The digitization of the pharmaceutical industry hits three or more different types of innovation sectors at once;  The bio/chemistry/clinical innovation that leads to new medicines; The device innovation that leads to dosing, data generation and tracking; and The digital/app/IT innovation that leads to rapid deployment, novel user interfaces, real-time interactions and analyses.  And we haven’t even mentioned marketing. A key problem is that none of these innovation centers speaks the language of the others.  Just as important, working styles, cultures and regulatory environments differ across these sectors.  These barriers lead to bogged projects, rework and gray hair.  So how do we bridge the language barrier, build teams and projects that work well together, and deliver the promise of the digital pharma space?  This talk will describe methods that you can use to address language, alignment and workstyle barriers to accelerate your transformations.

Digital transformation has transformed business processes, and connectivity has driven data liquidity. Data has become the new gold, providing insights and powering critical decisions. In a data-hungry world, data monetization has gained increasing importance. While the industry is still trying to optimize data strategies to drive ‘patient-centricity’, many questions remain unanswered.  This presentation will touch upon how the life sciences industry is trying to recognize the  value of data, models and strategies and who is really benefiting from the same.

DNAnexus and City of Hope Comprehensive Cancer Center (COH) embarked on a partnership to develop a scalable cloud-based oncology platform, POSEIDON, to democratize data for COH’s research and clinical programs, accelerating the fulfillment of its Precision Oncology strategy. POSEIDON leverages DNAnexus Apollo and Titan Platforms to combine multi-omics data in a unified environment that supports advanced analytics and visualizations within a collaboration portal to discover new evidence-based treatments and clinical pathways.